(163) A Novel Patient-Centered Real-World Evidence Study Designed to Better Understand Short Bowel Syndrome Using Longitudinal Data in the United States
Director, Quantitative Research Scientist Inspire, United States
Background: Short Bowel Syndrome (SBS) is a rare, chronic and debilitating condition that can be defined based upon intestinal dysfunction, i.e. the presence of significant malabsorption of both macro- and micro-nutrients. Evidence is limited with the real-world patient population.
Objectives: The aim of the study is to better understand patient demographics, diagnostic journey, healthcare resource utilization (HCRU) and treatment patterns of patients in the Inspire SBS cohort using primarily medical claims and user-generated contents.
Methods: A retrospective study using data from the Inspire Integrated Analytical Database, which links Inspire member data with medical and pharmacy claims through HIPAA-compliant tokenization. Inspire members with a combination of ICD-10 diagnosis and CPT/HCPCS codes for postsurgical nonabsorption and parenteral infusion from 01/01/2015 to 11/30/2021 were included. SBS index date is defined as the first service date with a CPT/HCPCS code for parenteral infusion that occurs on/after a claim with an ICD-10 code for post-surgical non-absorption (K91.2). Baseline patient characteristics and all-cause and SBS-related HCRU were evaluated. Descriptive statistics were reported.
Results: A total of 165 SBS patients were identified, with a median followup time of 51 months from index date. The median age at diagnosis is 52 and 79% of patients were female. Patients were geographically represented across the US. 84% of the cohort had ≥250 claims from a median of 26 care sites across 44 providers. The median number of hospitalizations was 4. 33% of patients previously had a diagnosis of unspecified anemia or malnutrition. Median time from the first diagnostic procedure to index diagnosis was 17 months. Top 5 most common topics viewed on Inspire among the cohort include: GI tract, Stomach, Feeding tube, Nausea and Small intestine.
Conclusions: SBS patients in this ongoing retrospective analysis had a median of over 4 years of healthcare visit data since diagnosis. Majority of patients had over 250 claims, which indicate substantial healthcare resource utilization. SBS patients endure a long diagnostic journey to undergo appropriate treatment.
