graduate student College of Pharmacy, Chungbuk National University, Cheongju, Republic of Korea, Republic of Korea
Background: Type2 Diabetic Mellitus(T2DM) is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. The chronic hyperglycemia of diabetes is associated with long-term damage, dysfunction, and failure of various organs, especially the eyes, kidneys, nerves, heart, and blood vessels.
Objectives: Although reports of T2DM have recently been increased, results are inconsistent regarding risk factors in Korean population. To investigate the risk factors of T2DM development, we conducted a case-control study using a large scale real-world data, Korean National Health Insurance Sharing Service data of 2002 to 2013. We included 208,285 patients who were newly diagnosed with T2DM as case cohort.
Methods: Control group included patients who were never diagnosed T2DM. Each case was 1:1 matched by age, sex, and follow-up duration to select control group. The differences in the categorical and continuous variables of the case and control groups were analyzed using a chi-squared test, logistic regression, and independent sample t-test, respectively. We deemed P < 0.05 as indicating statistical significance.
Results: After adjusting for potential confounders, rheumatoid arthritis (adjusted odd ratio (aOR)=1.36 confidence interval (CI)=1.33-1.40), ichemic heart disease (aOR=1.46 CI=1.43-1.49), and conventional synthetic disease modifying antirheumatic drugs (csDMARD) (aOR=1.60 CI=1.44-1.79) showed higher risk of T2DM than the control cohort.
Conclusions: This study showed that csDMARD is associated with higher risk of developing T2DM along with known factors such as hyperlipidemia, ischemic heart disease, and vascular disease
.jpg "Jun Hyeob Kim, BS photo")
