Methods

(254) Reverse Causation Bias: A Simulation Study Comparing First- and Second-Line Treatments With an Overlap of Symptoms Between Treatment Indication and Studied Outcome

(255) Evaluating bias from index date selection methods under varying assumptions in external control analyses using real-world comparators

(256) Leveraging External Validation Data to Address Misclassification: The Challenge of Transporting Misclassification Probabilities

(257) A Framework for Determining Sample Size for External Control Arms

(258) Examining the External Comparator Arm Design: A Simulation Study

(259) High-dose vs. standard-dose influenza vaccine and cardiopulmonary hospitalization or mortality: emulating the INVESTED trial using insurance claims data

(260) Risk of cardiovascular death and hospitalization for heart failure with sacubitril/valsartan vs. enalapril in clinical practice: application of outcome models developed with clinical trial data from PARADIGM-HF

(261) Development and Validation of a Claims-based Algorithm for Moderate-to-Severe Atopic Dermatitis

(262) How To Use High Dimensional Approach To Assist Non-Active Comparator Selection In The Retrospective Study: A Case Study For WATCHMAN Device

(263) Using claims data to identify the exact indication of use for biological drugs approved for Immune-Mediated Inflammatory Diseases: The VALORE project experience

(264) How can advanced analytics and innovative data visualizations improve the understanding of cancer healthcare pathways trajectories?

(265) Quality of Electronic Health Records: Variability of Missing Data for Social Determinants of Health by Healthcare Systems

(266) Development and Validation of a Tool to Assess Perceptions, Perspectives, Practice and Satisfaction in Patients Taking Oral anticoagulants

(267) Impact of using limited duration prevalence (LDP) vs. complete prevalence (CP) on racial/ethnic distributions derived from the Surveillance, Epidemiology, and End Results (SEER) database

(268) Evaluation of Commonly Used Real World Data Sources Submitted to ASCO Journals: Initial Steps Toward Furthering Transparent Reporting

(269) Measuring Inhaled Medication Compliance: A Study Using a Novel Developed Questionnaire

(270) Validation of Real-World Case Definitions for COVID-19 Diagnosis and Severe COVID-19 Illness Among Patients Infected with SARS-CoV-2: Translation of Clinical Trial Definitions to Real-World Settings

(271) Validation of a disability proxy for multiple sclerosis using digitized health records from the FlywheelMS cohort

(272) Development and Validation of Claims-based Algorithms for Conjunctivitis and Keratitis

(273) Comparing the performance of nested case-control and case-crossover study designs for assessing adverse outcomes of concomitant drug use: a simulation study

(274) Adapting the prevalent new-user study design to evaluate the effects of drug discontinuation: A simulation study

(275) Scalable natural language processing of electronic health records to supplement large-scale covariate adjustment in pharmacoepidemiologic studies

(276) Addressing bias due to socioeconomic status in the comparative effectiveness of sodium-glucose co-transporter 2 inhibitors vs. sulfonylureas in patients with type 2 diabetes

(277) Assessing joint covariate balance in matched observational studies with high-dimensional categorical variables

(278) Negative control outcome adjustment to tackle unmeasured confounding: A case study of oral quinolone and tendon rupture

(279) Time-varying propensity score matching as a method to balance baseline covariates and calendar time effects in a real-world effectiveness analysis